Wichtigste Eigenschaften
- Arbeitsort
- Wien, Wien
- Unternehmen
- Phagomed Biopharma GmbH
Allgemeine Beschreibung
in Vienna, Austria.Role description
- Lead a team of Researchers/Research Assistants, including training on working with bacteria, endolysins, working in a BSL-2 environment, application of experimental and documentation standards;
- Motivate, develop team members
- Establish research processes according to the latest microbiological technology developments (e.g. robotics and genomic data);
- Set-up and run library screenings for specific pathogens using the proprietary LysinBuilder toolkit
- Further establish and validate potency model for endolysins against bacteria in (mucosal) biofilm and planktonic growth;
- Assembly of bacterial panels for species of interest, including in silico analysis of geno- and serotypes, to ensure required genetical and geographical breadth;
- Genomic analyses of target bacteria and microbiome samples
- Analyze effect of endolysins on bacteria, including MIC, MBC, Cmax, AUC, resistance formation, in planktonic growth and on mucosal biofilms
- Evaluate immune response to endolysins
- Establish standardized experimental protocols that will enable reproducibility in later GLP studies (e.g. potency, endolysin effect on the immune system);
- Documentation of results according to the PhagoMed Quality Standards (GLP-like), to ensure the quality of results and their documentation are acceptable to regulatory authorities, working towards a human clinical trial application;
- Drafting of patent claims as appropriate, publication of selected results in scientific journals;
Mandatory requirements
- PhD or equivalent in microbiology, cell biology, protein biochemistry or structural biology;
- Excellent publication track record in a relevant field;
- Highly structured thinking;
- Interest in targeted pharmaceutical development;
- Interest in working in a team of highly skilled and motivated professionals;
- Fluent in English
Welcome add-on qualifications
- Experience with endolysins or other types of recombinant proteins
- Experience with molecular cloning, combinatorial methods, library screening
- Experience in research on antibiotics, e.g. resistance formation
- Experience in bacterial genetics, bioinformatics or genomic analyses
- Experience in pharmaceutical research in a start-up/ company
What we offer
- Become part of developing a new drug class in anti-infectives
- Take full responsibility for key elements of the PhagoMed development plan
- Pioneer new methods and processes to industrialize key research techniques
- Be part of a highly motivated, multinational and fun team that believes phage-based therapies can be part of the solution to the global antibiotics crisis
- A competitive compensation package that reflects the qualifications and seniority of the candidate. Due to legal requirements, we are required to state that the minimum salary for this job is a monthly salary of EUR 3.500,-- gross.
Interested? Please contact us!
Feel free to reach out directly if you have specific questions:
Dr. Lorenzo Corsini,
CEO | Research & Development, PhagoMed Biopharma GmbH
[Apply online]
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